WRN degrader 14c | WRN degrader | Probechem Biochemicals

Chemical Structure : WRN degrader 14c

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WRN degrader 14c (LdCHT 14c)

货号: PC-25461Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WRN degrader 14c is a potent, selective degrader of Werner syndrome helicase (WRN) with DC50 of 1.7 uM in MSI-H HCT116 cells, covalently conjugates to C727 within the WRN helicase domain, forming an adamantane-tagged adduct that initiates sustained proteasomal degradation.
WRN degrader 14c induces potent, highly selective and sustained WRN degradation, outperforming the parental inhibitor H3B-219, with negligible impact on other tested proteins even at 25 uM.
WRN degrader 14c induces WRN degradation through the ubiquitin proteasome system.
WRN degrader 14c exhibits superior antiproliferative and antimetastatic efficacy than H3B-219.
WRN degrader 14c induces significant apoptosis, cell cycle arrest and DNA damage in HCT-116 cells.

物理化学性质&存储条件

分子量	727.84
分子式	C37H44F3N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Tao W, et al. Eur J Med Chem. 2025 Sep 4;300:118121.

WRN degrader 14c (LdCHT 14c)

生物&药学活性

物理化学性质&存储条件

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WRN degrader 14c (LdCHT 14c)

生物&药学活性

物理化学性质&存储条件

参考文献

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