WEHI-P4

Chemical Structure : WEHI-P4

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货号: PC-24429Not For Human Use, Lab Use Only.

WEHI-P4 is a highly potent, specific SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 19 nM and KD of 18 nM, cellular EC50 of 330 nM in in-cell FRET-based biosensor assays.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

WEHI-P4 is a highly potent, specific SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 19 nM and KD of 18 nM, cellular EC50 of 330 nM in in-cell FRET-based biosensor assays.
WEHI-P4 displayed an antiviral EC50 of 410 nM in Vero plaque live virus infection assays, does not require auxiliary Pgp inhibition for its antiviral efficacy.
WEHI-P4 inhibits SARS-CoV-2 and SARS-CoV, and surprisingly also shows weak activity (IC50=52 µM) against PL2pro of the αCoV NL63, which has only 20% sequence identity to SARS-CoV-2.

物理化学性质&存储条件

分子量	396.53
分子式	C24H32N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-((R)-1-((1s,4S)-4-hydroxycyclohexyl)piperidin-3-yl)(6-methoxynaphthalen-2-yl)methanone O-methyl oxime

参考文献

1. M Bader S, et al. Nat Commun. 2025 Apr 3;16(1):2900.

WEHI-P4

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物理化学性质&存储条件

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WEHI-P4

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物理化学性质&存储条件

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