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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Ephrin Receptor-WCDD301
WCDD301

Chemical Structure : WCDD301

CAS No.: 2353-29-9

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WCDD301 (WCDD 301)

货号: PC-21784Not For Human Use, Lab Use Only.

WCDD301 is a high-affinity, orally available agonist of EphA4 receptor, competitively binds to the EphA4 receptor Ki of 0.13 uM, functions as an EphA4 agonist and competes with the natural ligand, Ephrin-A5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WCDD301 is a high-affinity, orally available agonist of EphA4 receptor, competitively binds to the EphA4 receptor Ki of 0.13 uM, functions as an EphA4 agonist and competes with the natural ligand, Ephrin-A5.
    WCDD301 suppresses glucagon secretion in murine α cells by binding to EphA4 receptor.
    WCDD301 suppresses glucagon secretion from human α cells in both healthy and type 1 diabetic participants.
    WCDD301 enhances intracellular F-actin and EphA4 intensities in both human and mouse dispersed islet cells.
    WCDD301 recovers mononuclear cell infiltrate and restores F-actin and EphA4 intensities in islets of NOD diabetic mice.
    WCDD301 normalizes blood glucose levels in diabetic mouse models that is accompanied by improvement in glucose tolerance.
    WCDD301 does not alter plasma levels of GLP-1, glutamine, and somatostatin and normalizes hyperglucosuria, polyphagia, and weight loss in diabetic NOD mice.
     

    物理化学性质&存储条件

    分子量 247.25
    分子式 C10H17NO6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(acetoxymethyl)-2-aminopropane-1,3-diyl diacetate

    参考文献

    1. Farzad Asadi, et al. JCI Insight. 2024 Jan 23;9(2):e172626.

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