WCDD115

Chemical Structure : WCDD115

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货号: PC-24522Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

WCDD115 is a potent indirect inhibitor of NRF2 expression with IC50 of 57 nM (inhibition of eYFP quantitation in H1299 NQO1-eYFP cells), inhibits hDHFR with IC50 of 144 nM, suppresses endogenous metrics of NRF2 signal transduction irrespective of KEAP1 expression.
WCDD115 suppresses endogenous NRF2 signaling and increases DHFR protein in NRF2-active KYSE70 and A549 cells.
WCDD115 suppresses the RNA level expression of NRF2, NQO1, GCLC, and SXRN1 with similar efficacy。
Inhibition of DHFR is required for WCDD115-mediated suppression of NRF2.

物理化学性质&存储条件

分子量	282.27
分子式	C13H13F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-ethyl-5-(3-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine

参考文献

1. Chembo J, et al. bioRxiv [Preprint]. 2025 Feb 17:2025.02.13.637433.

WCDD115

生物&药学活性

物理化学性质&存储条件

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WCDD115

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物理化学性质&存储条件

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