WBC100 (WBC-100)

Chemical Structure : WBC100

CAS No.: 2095780-08-6

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货号: PC-72923Not For Human Use, Lab Use Only.

WBC100 (WBC-100) is a novel potent, oral active that selectively degrades c-Myc protein over other proteins and potently kills c-Myc overexpressing cancer cell.

规格	价格	库存
1 mg	￥2280	In stock
5 mg	￥5480	In stock
10 mg	￥7980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WBC100 (WBC-100) is a novel potent, oral active that selectively degrades c-Myc protein over other proteins and potently kills c-Myc overexpressing cancer cell.
selectively kills c-Myc overexpressing cancer cells Mia-paca2 (PDAC), H9 (T-cell lymphoma), and
MOLM-13 (acute myeloid leukemia) with IC5 of 61, 17 and 16 nM, respectively.
WBC100 targets the nuclear localization signal 1 (NLS1)-Basic-nuclear localization signal 2 (NLS2) region of c-Myc and induces c-Myc protein degradation through ubiquitin E3 ligase CHIP mediated 26S proteasome pathway, leading to apoptosis of cancer cells.
WBC100 potently regresses multiple lethal c-Myc overexpressing tumors such as acute myeloid leukemia, pancreatic, and gastric cancers with good tolerability in multiple xenograft mouse models.

物理化学性质&存储条件

分子量	459.539
分子式	C25H33NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl L-valinate

参考文献

1. Xu Y, et al. Adv Sci (Weinh). 2022 Jan 20:e2104344.

WBC100 (WBC-100)

生物&药学活性

物理化学性质&存储条件

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WBC100 (WBC-100)

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