WB518 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : WB518

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WB518 (WB-518)

货号: PC-26626Not For Human Use, Lab Use Only.

WB518 is a specific small molecule STAT3 inhibitor, inhibits the phosphorylation of STAT3 Tyr705 (Y705).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

WB518 is a specific small molecule STAT3 inhibitor, inhibits the phosphorylation of STAT3 Tyr705 (Y705).
WB518 impairs STAT3 activity and decreases the expression of K17 induced by IL-17A/IL-22 in HaCaT cells, without affecting the ERK or STAT1 pathway.
Topical WB518 application ameliorates IMQ-induced psoriasis-like dermatitis.
WB518 treatment significantly ameliorates the development of the scaling and erythema.
WB518 reduces the infiltration of CD3-positive T cells in IMQ-induced mouse skin.
WB518 ameliorates TPA-induced psoriasis-like skin inflammation.
Topical application of WB518 decreases TPA-induced inflammation through STAT3 inhibition.

物理化学性质&存储条件

分子量	518.34
分子式	C20H16BrN5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 6-(5-bromofuran-2-carbonyl)-3-cyano-2-(1-methyl-1H-pyrazole-4-carboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-4-carboxylate

参考文献

1. Ti C, et al. Int Immunopharmacol. 2024 Jan 25;127:111344.

WB518 (WB-518)

生物&药学活性

物理化学性质&存储条件

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WB518 (WB-518)

生物&药学活性

物理化学性质&存储条件

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