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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Dickkopf-1 (Dkk-1)-WAY-262611
WAY-262611

Chemical Structure : WAY-262611

CAS No.: 1123231-07-1

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WAY-262611 (WAY262611, WAY 262611)

货号: PC-42795Not For Human Use, Lab Use Only.

WAY-262611 (WAY262611) is a potent, orally active and Wnt/β-catenin pathway agonist with EC50 of 0.63 nM, via inhibition of dickkopf-1 (DKK-1).

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥1080 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WAY-262611 (WAY262611) is a potent, orally active and Wnt/β-catenin pathway agonist with EC50 of 0.63 nM, via inhibition of dickkopf-1 (DKK-1).
WAY-262611 increases bone formation rate in ovariectomized rats.
WAY-262611 inhibits cell migration of fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis.

物理化学性质&存储条件

分子量 318.4155
分子式 C20H22N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 42 mg/mL
Chemical Name/SMILES

4-Piperidinemethanamine, 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-

参考文献

1. Pelletier JC, et al. J Med Chem. 2009 Nov 26;52(22):6962-5.

2. Enochson L, et al. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77.

3. Choe JY, et al. Rheumatology (Oxford). 2016 May;55(5):928-38.

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