W478

Chemical Structure : W478

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货号: PC-25612Not For Human Use, Lab Use Only.

W478 is a potent novel serine hydroxymethyltransferase 2 (SHMT2) inhibitor with IC50 of 1.21 uM, binds to SHMT2 with ITC KD of 10.6 uM.

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生物&药学活性

W478 is a potent novel serine hydroxymethyltransferase 2 (SHMT2) inhibitor with IC50 of 1.21 uM, binds to SHMT2 with ITC KD of 10.6 uM.
W478 inhibits the proliferation of esophageal cancer cell with IC50 values of 1.62 and 1.18 μM toward KYSE-450 and KYSE-70 cells.
W478 (2.5 uM) inhibits the migration and invasion of esophageal cancer cell.
W478 induces esophageal cancer cell cycle arrest, promotes esophageal cancer cell apoptosis.
W478 enhances the production of reactive oxygen species (ROS) in esophageal cancer cell.

物理化学性质&存储条件

分子量	558.03
分子式	C26H16ClN7O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-(4-chlorophenyl)-5-cyano-6-((1-phenyl-1H-tetrazol-5-yl)thio)pyrimidin-2-yl)thio)methyl)benzoic acid

参考文献

1. Akram HMB, et al. Bioorg Chem. 2025 Sep 23;165:109028.

W478

生物&药学活性

物理化学性质&存储条件

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W478

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物理化学性质&存储条件

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