Vps34-IN-1 |CAS:1383716-33-3 Probechem Biochemicals

Chemical Structure : Vps34-IN-1

CAS No.: 1383716-33-3

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Vps34-IN-1 (Vps34-IN1)

货号: PC-43214Not For Human Use, Lab Use Only.

Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases.
Vps34-IN-1 rapidly reduces endosomal PtdIns(3)P levels, induces a rapid ~50-60% loss of SGK3 phosphorylation in cells, does not inhibit activity of the SGK2 isoform.
Vps34-IN1 is a useful probe to delineate physiological roles of the Vps34.

物理化学性质&存储条件

分子量	425.9146
分子式	C21H24ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	2-Propanol, 1-[[2-[(2-chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-

参考文献

1. Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27.

2. Valet C, et al. Blood. 2017 Nov 2;130(18):2032-2042.

Vps34-IN-1 (Vps34-IN1)

生物&药学活性

物理化学性质&存储条件

参考文献

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Vps34-IN-1 (Vps34-IN1)

生物&药学活性

物理化学性质&存储条件

参考文献

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