Vonoprazan (TAK-438 free base) | H(+),K(+)-ATPase inhibitor

Chemical Structure : Vonoprazan

CAS No.: 881681-00-1

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Vonoprazan (TAK438, TAK-438)

货号: PC-42022Not For Human Use, Lab Use Only.

Vonoprazan (TAK-438 free base) is a potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM.

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100 mg	￥380	In stock
250 mg	￥580	In stock
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生物&药学活性

Vonoprazan (TAK-438 free base) is a potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM.
Vonoprazan completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats (4mg/kg, p.o.).
Vonoprazan increases the pH of gastric perfusate to a higher value, and sustains longer than those of lansoprazole or SCH28080.
Vonoprazana is a clinical candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.

物理化学性质&存储条件

分子量	345.3912
分子式	C17H16FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-

参考文献

1. Arikawa Y, et al. J Med Chem. 2012 May 10;55(9):4446-56.

2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):231-8.

3. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):412-20.

Vonoprazan (TAK438, TAK-438)

生物&药学活性

物理化学性质&存储条件

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Vonoprazan (TAK438, TAK-438)

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物理化学性质&存储条件

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