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Varlitinib

Chemical Structure : Varlitinib

CAS No.: 845272-21-1

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Varlitinib (ARRY-334543;ARRY334543)

货号: PC-42640Not For Human Use, Lab Use Only.

Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2.

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10 mg ￥1520 In stock
50 mg ￥4320 In stock
100 mg ￥5920 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2; significantly reverses ABCG2-MDR by directly inhibiting the drug efflux function of ABCG2 at 1.0 uM; significantly reverses drug resistance mediated by ABCG2.

Thyroid Cancer

Approved

物理化学性质&存储条件

分子量 466.9433
分子式 C22H19ClN6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 16.67 mg/mL
Chemical Name/SMILES

4,6-Quinazolinediamine, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-

参考文献

1. Wang DS, et al. J Cell Biochem. 2014 Aug;115(8):1381-91.

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