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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU625
VU625

Chemical Structure : VU625

CAS No.: 901008-62-6

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VU625 (VU0077625)

货号: PC-25403Not For Human Use, Lab Use Only.

VU625 (VU0077625) is a potent and selective inhibitor of Aedes aegypti Kir1 (AeKir1) channel with IC50 of 96.8 nM in patch clamp electrophysiology experiments of HEK293 cells, selective for AeKir1 over mammalian Kir channels and AeKir2B channel.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU625 (VU0077625) is a potent and selective inhibitor of Aedes aegypti Kir1 (AeKir1) channel with IC50 of 96.8 nM in patch clamp electrophysiology experiments of HEK293 cells, selective for AeKir1 over mammalian Kir channels and AeKir2B channel.
VU625 inhibits AeKir1- and AeKir2B-mediated K+ currents with IC50 values of 3.8 µM and 45.1 µM respectively.

物理化学性质&存储条件

分子量 374.46
分子式 C19H22N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-methoxyphenyl)-2-methyl-1-propionylindoline-5-sulfonamide

参考文献

1. Raphemot R, et al. PLoS One. 2014 Nov 6;9(11):e110772.

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