VU6045422

Chemical Structure : VU6045422

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货号: PC-24341Not For Human Use, Lab Use Only.

VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).

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生物&药学活性

VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).
VU6045422 does not induce a significant long-term depression of fEPSPs in the mouse layer 5 prefrontal cortex.
VU6045422 was significantly more stable than VU0467319, but was found less stable in liver microsomes.

物理化学性质&存储条件

分子量	395.42
分子式	C22H11D5F2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-difluoro-4-(2-(methyl-d3)-2H-indazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one-7,7-d2

参考文献

1. Engers JL, et al. ACS Chem Neurosci. 2025 Mar 25. doi: 10.1021/acschemneuro.5c00119.

VU6045422

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物理化学性质&存储条件

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VU6045422

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物理化学性质&存储条件

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