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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU6032735
VU6032735

Chemical Structure : VU6032735

CAS No.:

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VU6032735 (VU-6032735)

货号: PC-25544Not For Human Use, Lab Use Only.

VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG.
VU6032735 inhibits mouse SLO3 currents with IC50 of 730 nM.

物理化学性质&存储条件

分子量 525.45
分子式 C25H21F6N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-((4-(trifluoromethoxy)benzyl)oxy)phenyl)(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone

参考文献

1. Temple KJ, et al. ACS Pharmacol Transl Sci. 2025 Aug 15;8(9):3281-3295.

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