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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU6007477
VU6007477

Chemical Structure : VU6007477

CAS No.: 2220141-46-6

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VU6007477 (VU 6007477)

货号: PC-35747Not For Human Use, Lab Use Only.

VU6007477 is a potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU6007477 is a potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity.
VU6007477 displays high selectivity against M2-M5.

物理化学性质&存储条件

分子量 430.512
分子式 C24H26N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-methyl-4-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridine-6-carboxamide

参考文献

1. Engers JL, et al. ACS Med Chem Lett. 2018 Sep 4;9(9):917-922.

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