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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU0529331
VU0529331

Chemical Structure : VU0529331

CAS No.: 1286725-49-2

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VU0529331 (VU 0529331, VU-0529331)

货号: PC-35862Not For Human Use, Lab Use Only.

VU0529331 (VU 0529331) is the first synthetic small molecule activator of non-GIRK1-containing GIRK (non-GIRK1/X) channels with EC50 of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively.

规格 价格 库存 数量
5 mg ￥2980 In stock
10 mg ￥4580 In stock
25 mg ￥7280 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0529331 (VU 0529331) is the first synthetic small molecule activator of non-GIRK1-containing GIRK (non-GIRK1/X) channels with EC50 of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively.
VU0529331 can specifically modulate the activity of GIRK1-containing GIRK channels.

物理化学性质&存储条件

分子量 384.443
分子式 C22H20N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-(3,4-dimethylphenyl)-3-(1H-pyrrol-1-yl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)(pyrazin-2-yl)methanone

参考文献

1. Kozek KA, et al. ACS Chem Neurosci. 2018 Sep 13. doi: 10.1021/acschemneuro.8b00287.

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