VU041 | Mosquito Kir1 inhibitor | Probechem Biochemicals

Chemical Structure : VU041

CAS No.: 332943-64-3

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VU041 (VU-041)

货号: PC-26449Not For Human Use, Lab Use Only.

VU041 is a selective inhibitor of mosquito Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium (Kir) channels with IC50 of 496 nM for AnKir1.

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生物&药学活性

VU041 is a selective inhibitor of mosquito Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium (Kir) channels with IC50 of 496 nM for AnKir1.
VU041 preferentially inhibited AeKir1 over AeKir2B in two-electrode voltage clamp experiments in Xenopus oocytes.
VU041 does not inhibit mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1 with IC50 of <30 uM.
VU041 is equally toxic to insecticide-susceptible and -resistant strains of mosquitoes.
VU041 inhibits renal excretory function in mosquitoes, overcomes insecticide-resistance.

物理化学性质&存储条件

分子量	363.38
分子式	C19H20F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dihydroquinolin-1(2H)-yl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)ethan-1-one

参考文献

1. Swale DR, et al. Sci Rep. 2016 Nov 16;6:36954.

2. Rusconi Trigueros R, et al. Insects. 2018 Nov 15;9(4):163.

VU041 (VU-041)

生物&药学活性

物理化学性质&存储条件

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VU041 (VU-041)

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物理化学性质&存储条件

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