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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU0364572 TFA
VU0364572 TFA

Chemical Structure : VU0364572 TFA

CAS No.: 1240514-89-9

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VU0364572 TFA

货号: PC-26730Not For Human Use, Lab Use Only.

VU0364572 TFA is a potent, selective, orally active, allosteric agonist of M1 muscarinic receptor with an EC50 of 0.11 uM, shows neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's disease.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0364572 TFA is a potent, selective, orally active, allosteric agonist of M1 muscarinic receptor with an EC50 of 0.11 uM, shows neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's disease.

物理化学性质&存储条件

分子量 487.52
分子式 C23H32F3N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethyl (R)-3-(2-methylbenzamido)-[1,4'-bipiperidine]-1'-carboxylate 2,2,2-trifluoroacetate

参考文献

1. Lebois EP, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1177-1187.

2. Lebois EP, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6451-5.

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