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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU0357017 hydrochloride
VU0357017 hydrochloride

Chemical Structure : VU0357017 hydrochloride

CAS No.: 1135242-13-5

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VU0357017 hydrochloride (VU 0357017 hydrochloride, ML071)

货号: PC-45705Not For Human Use, Lab Use Only.

VU0357017 hydrochloride (ML071) is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0357017 hydrochloride (ML071) is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.
VU0357017 displays good selectivity versus M2-M5 and a large panel of GPCRs, ion channels, and transporters.
VU0357017 shows excellent brain exposure and robust in vivo efficacy in rodent model.

物理化学性质&存储条件

分子量 369.8862
分子式 C18H28ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

1-Piperidinecarboxylic acid, 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-, ethyl ester, hydrochloride (1:1)

参考文献

1. Lebois EP, et al. ACS Chem Neurosci. 2010;1(2):104-121.

2. Digby GJ, et al. J Neurosci. 2012 Jun 20;32(25):8532-44.

3. Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

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