VU0285655-1 (BML280) | PLD2 inhibitor | Probechem Biochemicals

Chemical Structure : VU0285655-1

CAS No.: 1158347-73-9

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VU0285655-1 (BML280, VU0285655)

货号: PC-72955Not For Human Use, Lab Use Only.

VU0285655-1 (BML280) is a potent, selective PLD2 inhibitor with IC50 of 90 nM, 21-fold selective over PLD1, prevents caspase-3 cleavage and reduction in cell viability induced by high glucose, induces autophagy in colorectal cancer cells.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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生物&药学活性

VU0285655-1 (BML280) is a potent, selective PLD2 inhibitor with IC50 of 90 nM, 21-fold selective over PLD1, prevents caspase-3 cleavage and reduction in cell viability induced by high glucose, induces autophagy in colorectal cancer cells.

物理化学性质&存储条件

分子量	465.98
分子式	C25H28ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide hydrochloride

参考文献

1. Burkhardt U, et al. Eur J Pharmacol. 2015 Aug 15;761:398-404. 2. Robert Lavieri, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3.

VU0285655-1 (BML280, VU0285655)

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VU0285655-1 (BML280, VU0285655)

生物&药学活性

物理化学性质&存储条件

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