VT3989 | YAP/TEAD inhibitor | Probechem Biochemicals

Chemical Structure : VT3989

CAS No.: 2506273-81-8

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VT3989 (VT-3989)

货号: PC-26277Not For Human Use, Lab Use Only.

VT3989 is a first-in-class, orally bioavailable, selective and potent inhibitor of YAP/TEAD inhibitor, inhibits TEAD autopalmitoylation and disrupts YAP transcriptional activity.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

VT3989 is a first-in-class, orally bioavailable, selective and potent inhibitor of YAP/TEAD inhibitor, inhibits TEAD autopalmitoylation and disrupts YAP transcriptional activity.
VT3989 effectively binds to all four TEAD paralogs (TEAD1-TEAD4).
VT3989 strongly blocks palmitoylation of TEAD1 and TEAD3, also inhibits palmitoylation of TEAD2 and TEAD4.
VT3989 potently inhibit the proliferation of NF2-deficient (NCI-H226, GI50=9 nM) and NF2-mutated (NCI-H2052, GI50=9 nM) and NCI-H2373) cell lines but not NF2 wild-type, Merlin-positive cell lines.
VT3989 blocks NCI-H226 NF2-deficient xenograE tumor growth in mice.

物理化学性质&存储条件

分子量	389.37
分子式	C21H18F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-hydroxypropan-2-yl)-5-(4-(trifluoromethyl)phenoxy)-2-naphthamide

参考文献

1. Yap TA, et al. Nat Med. 2025 Dec;31(12):4281-4290.

VT3989 (VT-3989)

生物&药学活性

物理化学性质&存储条件

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VT3989 (VT-3989)

生物&药学活性

物理化学性质&存储条件

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