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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-VRK1/CK1-IN-1
VRK1/CK1-IN-1

Chemical Structure : VRK1/CK1-IN-1

CAS No.: 3050772-20-5

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VRK1/CK1-IN-1

货号: PC-26318Not For Human Use, Lab Use Only.

VRK1/CK1-IN-1 is a potent, dual inhibitor of Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) with Ki of 37.9 nM for VRK1, and IC50 of 17 nM and 15 nM for CK1δ and CK1ε, mimics the cellular outcomes of VRK1 depletion.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VRK1/CK1-IN-1 is a potent, dual inhibitor of Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) with Ki of 37.9 nM for VRK1, and IC50 of 17 nM and 15 nM for CK1δ and CK1ε, mimics the cellular outcomes of VRK1 depletion.

物理化学性质&存储条件

分子量 416.39
分子式 C19H18F2N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-((3,5-Difluoro-4-hydroxyphenyl)amino)-7,8-dimethyl-5-((3-methylisoxazol-5-yl)methyl)-7,8-dihydropteridin-6(5H)-one

参考文献

1. Fernando H de Souza Gama, et al. J Med Chem. 2024 Jun 13;67(11):8609-8629.

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