VPS4 inhibitor 4-107

Chemical Structure : VPS4 inhibitor 4-107

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货号: PC-24320Not For Human Use, Lab Use Only.

VPS4 inhibitor 4-107 is a DBeQ derivative and vacuolar protein sorting 4 (VPS4) AAA-ATPase inhibitor (IC50=3.7 uM, VPS4B), inhibits VPS4 ATPase activity, induces CASP8-mediated apoptosis.

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生物&药学活性

VPS4 inhibitor 4-107 is a DBeQ derivative and vacuolar protein sorting 4 (VPS4) AAA-ATPase inhibitor (IC50=3.7 uM, VPS4B), inhibits VPS4 ATPase activity, induces CASP8-mediated apoptosis.
VPS4 inhibitor 4-107 is modestly selective for VPS4B in vitro over VCP (IC50=8.6 uM).
VPS4 inhibitor 4-107 4-107 (1 μM) does not induce ER stress or the accumulation of polyubiquitinated proteins, unlike CB-5083.
VPS4 inhibitor 4-107 exhibits improved cellular potency and selectivity for VPS4 compared with DBeQ.
4-107 induces ESCRT accumulation on LC3-positive autophagosomal membranes.
4-107 exhibits lysosomotropic properties and disrupts endolysosomal membrane integrity.
4-107 induces CASP8-mediated VPS4-sensitive cell death
4-107 (5 mg/kg/day, i.p.) suppresses tumor growth in syngeneic mouse model of neuroblastoma, without causing severe toxicity in mice.

物理化学性质&存储条件

分子量	370.46
分子式	C23H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2,N4-dibenzyl-8-methoxyquinazoline-2,4-diamine

参考文献

1. Fundora KA, et al. J Pharmacol Exp Ther. 2025 Feb 28;392(4):103524.