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首页-小分子抑制剂&激动剂-Others-Spliceosome-VPC-80051
VPC-80051

Chemical Structure : VPC-80051

CAS No.: 877969-69-2 (Racemate)

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VPC-80051 (VPC80051)

货号: PC-36117Not For Human Use, Lab Use Only.

VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1.

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10 mg ￥1680 In stock
25 mg ￥2680 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1.
VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line, reduces AR-V7 mRNA levels.

物理化学性质&存储条件

分子量 301.297
分子式 C16H13F2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1-(3,4-difluorophenyl)ethyl)-2H-indazole-3-carboxamide

参考文献

1. Carabet LA, et al. Molecules. 2019 Feb 20;24(4). pii: E763.

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