VP-14637 (MDT-637) | RSV fusion inhibitor | Probechem Biochemicals

Chemical Structure : VP-14637

CAS No.: 235106-62-4

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VP-14637 (MDT-637, MDT637, VP14637)

货号: PC-63268Not For Human Use, Lab Use Only.

VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function.

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生物&药学活性

VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function.
VP-14637 does not block RSV adsorption but inhibits RSV-induced cell-cell fusion and binds specifically to RSV-infected cells, specifically interacts with the RSV fusion protein expressed by a T7 vaccinia virus system.
The F proteins containing the resistance mutations exhibits greatly reduced binding of VP-14637.

物理化学性质&存储条件

分子量	510.5
分子式	C25H22N10O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-[(4-Hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]phenol]

参考文献

1. Kim YI, et al. Influenza Other Respir Viruses. 2017 Nov;11(6):525-530.

2. Douglas JL, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6.

3. Douglas JL, et al. J Virol. 2003 May;77(9):5054-64.

VP-14637 (MDT-637, MDT637, VP14637)

生物&药学活性

物理化学性质&存储条件

参考文献

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VP-14637 (MDT-637, MDT637, VP14637)

生物&药学活性

物理化学性质&存储条件

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