VH4004280 | HIV-1 capsid inhibitor | Probechem Biochemicals

Chemical Structure : VH4004280

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VH4004280 (VH-280)

货号: PC-25439Not For Human Use, Lab Use Only.

VH4004280 (VH-280) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.093 nM and 0.23 nM respectively.

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100 mg		Get quote

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生物&药学活性

VH4004280 (VH-280) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.093 nM and 0.23 nM respectively.
VH4004280 (VH-280) exhibits antiviral activity against additional viral strains with E50 of 0.085-0.48 nM.
VH4004280 (VH-280) inhibits a broad spectrum of HIV-1 isolates, and chimeric viruses derived from sequences of multiple group M subtypes, including subtypes A, B, C, F, G, and CRF01_AE.
VH4004280 (VH-280) also blocks nuclear import, total reverse transcript production, integration, virion assembly, and maturation.

物理化学性质&存储条件

分子量	950.24
分子式	C41H29ClF9N9O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-7-(6-(trifluoromethyl)pyridin-2-yl)-3,4-dihydroquinazolin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

参考文献

1. Wang C, et al. Antimicrob Agents Chemother. 2025 Sep 3:e0030925.

VH4004280 (VH-280)

生物&药学活性

物理化学性质&存储条件

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VH4004280 (VH-280)

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