VH298 |CAS:2097381-85-4 Probechem Biochemicals

Chemical Structure : VH298

CAS No.: 2097381-85-4

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VH298 (VH-298;VH298)

货号: PC-61056Not For Human Use, Lab Use Only.

VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.
VH 298 selectively engages VHL as its prime cellular target and is not toxic to cells, induces concentration- and time-dependent on-target specific accumulation of hydroxylated HIF-α in human cell lines.
VH 298 induces HIF transcriptional activity and upregulates HIF-dependent response gene products, elicits a HIF-dependent hypoxic response in various cell lines.

物理化学性质&存储条件

分子量	523.652
分子式	C27H33N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Soares P, et al. J Med Chem. 2017 Sep 18. doi: 10.1021/acs.jmedchem.7b00675.

2. Frost J, et al. Nat Commun. 2016 Nov 4;7:13312.

VH298 (VH-298;VH298)

生物&药学活性

物理化学性质&存储条件

参考文献

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VH298 (VH-298;VH298)

生物&药学活性

物理化学性质&存储条件

参考文献

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