Sebrinoflast (VENT-02) | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : VENT-02

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VENT-02 (Sebrinoflast, VENT02)

货号: PC-26681Not For Human Use, Lab Use Only.

Sebrinoflast (VENT-02) is a potent, selective, orally bioavailable, central nervous system (CNS)-penetrant, and reversible inhibitor of NLRP3, inhibits IL-1β and IL-18 release in ATP stimulated LPS-primed whole blood with IC50 of 0.19 and 0.17 uM respectively.

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生物&药学活性

Sebrinoflast (VENT-02) is a potent, selective, orally bioavailable, central nervous system (CNS)-penetrant, and reversible inhibitor of NLRP3, inhibits IL-1β and IL-18 release in ATP stimulated LPS-primed whole blood with IC50 of 0.19 and 0.17 uM respectively.
VENT-02 inhibitsIL-1β and IL-18 release in a concentration-dependent manner following LPS stimulation of human iPSC-derived microglia with IC50 of 6.1 nM.
VENT-02 inhibits IL-18 release in following LPS stimulation of human iPSC-derived microglia with IC50 of 6.3 nM.
VENT-02 doesnot inhibit TNFa release.
VENT-02 binds to a specific pocket on the monomeric form of NLRP3, stabilizing the inactive conformation and preventing the conformational changes necessary for oligomerization and full inflammasome activation.

物理化学性质&存储条件

分子量	350.42
分子式	C20H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(4-((5,5-dimethyltetrahydrofuran-3-yl)amino)pyrido[3,4-d]pyridazin-1-yl)-5-methylphenol

参考文献

1. Smidt LCA, et al. Clin Transl Sci. 2026 May;19(5):e70578.

VENT-02 (Sebrinoflast, VENT02)

生物&药学活性

物理化学性质&存储条件

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VENT-02 (Sebrinoflast, VENT02)

生物&药学活性

物理化学性质&存储条件

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