VCP979 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : VCP979

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VCP979 (VCP-979)

货号: PC-49694Not For Human Use, Lab Use Only.

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生物&药学活性

VCP979 (VCP-979) is a novel selective small molecule p38 MAPK inhibitor with a significantly greater affinity for the active form of p38 MAPK, has significant anti-fibrotic effects in vitro and in vivo.
VCP979 significantly promoted axonal/white matter (WM) remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice.
VCP979 improved axonal/WM remodeling and functional outcomes in a diabetic mouse stroke mode.
VCP979 effectively suppressed orthotopic pancreatic cancer growth and metastasis.
VCP979 effectively reduced renal fibrosis, extracellular matrix accumulation, and alleviated epithelial-mesenchymal transition in UUO rats.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Cai Y, et al. J Biomed Nanotechnol. 2018 Mar 1;14(3):585-593.

2. Liu J, et al. Int J Mol Med. 2020 Feb;45(2):353-364.

3. Min S, et al. Exp Biol Med (Maywood). 2023 Jan 30:15353702221147569.

4. Natalie B Vinh, et al. ChemistryOpen. 2015 Feb;4(1):56-64.

VCP979 (VCP-979)

生物&药学活性

物理化学性质&存储条件

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VCP979 (VCP-979)

生物&药学活性

物理化学性质&存储条件

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