VBIT-4 | VDAC1 inhibitor | Probechem Biochemicals

Chemical Structure : VBIT-4

CAS No.: 2086257-77-2

加入收藏

VBIT-4 (VBIT4)

货号: PC-25198Not For Human Use, Lab Use Only.

VBIT-4 is a specific, small molecule inhibitor of VDAC1 oligomerization with IC50 of 1.9 uM, directly interact with purified VDAC1 (MST, Kd=17 uM) and reduces channel activity.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VBIT-4 is a specific, small molecule inhibitor of VDAC1 oligomerization with IC50 of 1.9 uM, directly interact with purified VDAC1 (MST, Kd=17 uM) and reduces channel activity.
VBIT-4 inhibits Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50 of 1.8 uM.
VBIT-4 (10 uM) effectively inhibits selenite-induced VDAC1 oligomerization and cell death in HEK-293 cells.
VBIT-4 (20 uM) inhibits VDAC1 oligomerization and apoptosis in neuronal cell SH-SY5Y and Bax/Bak-lacking MEFs cells.
VBIT-4 decreases mtDNA release, IFN signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.

物理化学性质&存储条件

分子量	457.88
分子式	C21H23ClF3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide

参考文献

1. Ben-Hail D, et al. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

2. Kim J, et al. Science. 2019 Dec 20;366(6472):1531-1536.

VBIT-4 (VBIT4)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

VBIT-4 (VBIT4)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.