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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-Ursocholic acid
Ursocholic acid

Chemical Structure : Ursocholic acid

CAS No.: 2955-27-3

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Ursocholic acid (UCA)

货号: PC-26884Not For Human Use, Lab Use Only.

Ursocholic acid (UCA) is a natural bile acid with established cholesterol-lowering properties, is a direct AMPK agonist and promotes Thr172 phosphorylation, and downregulates lipogenic genes (SREBF1, LPIN1, FASN, SCD1).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ursocholic acid (UCA) is a natural bile acid with established cholesterol-lowering properties, is a direct AMPK agonist and promotes Thr172 phosphorylation, and downregulates lipogenic genes (SREBF1, LPIN1, FASN, SCD1).
Ursocholic acid dose-dependently reduced hepatic lipid accumulation in vitro and in vivo.
Ursocholic acid ameliorates hepatic steatosis via direct AMPK activation in preclinical models of MASLD.
Ursocholic acid shows activities of anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling.

物理化学性质&存储条件

分子量 408.58
分子式 C24H40O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

参考文献

1. Batta AK, et al. Am J Gastroenterol. 1997 Jun;92(6):1035-7.

2. Li Y, et al. Eur J Pharmacol. 2026 May 12;1026:178964.

3. Tint GS, et al. Hepatology. 1992 Apr;15(4):645-50.

4. Xu G, et al. J Biol Chem. 2002 Dec 27;277(52):50491-6.

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