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首页-抗体和重组蛋白-Biosimilar Antibody-Urelumab
Urelumab

Chemical Structure : Urelumab

CAS No.: 934823-49-1

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Urelumab (Anti-human CD137-hIgG4P mAb, human IgG4P-Kappa)

货号: PC-Ab1012Not For Human Use, Lab Use Only.

Urelumab is an agonist antibody to CD137 with potential application as an immuno-oncology therapeutic, enhances NK-cell activation increasing CD25 expression and IFNɣ production, but not in vitro ADCC. Urelumab enhances T-cell and natural killer-cell antitumor activity in preclinical models, and may enhance cytotoxic activity of rituximab..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Urelumab is an agonist antibody to CD137 with potential application as an immuno-oncology therapeutic, enhances NK-cell activation increasing CD25 expression and IFNɣ production, but not in vitro ADCC. Urelumab enhances T-cell and natural killer-cell antitumor activity in preclinical models, and may enhance cytotoxic activity of rituximab.

物理化学性质&存储条件

分子量
分子式 Human IgG4P-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Urelumab; BMS-663513; Anti-4-1BB antibody; CD137; Anti-human 4-1BB; TNFRSF9

参考文献

1. 1, Srivastava RM, et al. Clin Cancer Res. 2017 Feb 1;23(3):707-716. 2, Ho SK, et al. Mol Cancer Ther. 2020 Apr;19(4):1040-1051.  3, Cabo M, et al. Cancer Immunol Res. 2021 Sep 27. doi: 10.1158/2326-6066.CIR-21-0030. 4, Harao M, et al. Cancer Immunol Res. 2017 Jun;5(6):439-445.

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