Urantide

Chemical Structure : Urantide

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货号: PC-28278Not For Human Use, Lab Use Only.

Urantide is a potent, selective, peptidic urotensin-II receptor (U-II, UT receptor) antagonist, blocks hU-II-induced contractions in rat isolated thoracic aorta with pKb of 8.3.

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生物&药学活性

Urantide is a potent, selective, peptidic urotensin-II receptor (U-II, UT receptor) antagonist, blocks hU-II-induced contractions in rat isolated thoracic aorta with pKb of 8.3.
Urantide is able to modify noradrenaline- or endothelin 1-induced contractile effects.
Urantide displaces [125I]urotensin II from specific binding at hU-II recombinant receptors (UT receptors) transfected into CHO/K1 cells with pKi of 8.3.
Urantide is a competitive, potent (pA2 8.24), and pure antagonist in the rat aorta bioassay.
Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.

物理化学性质&存储条件

分子量	1075.26
分子式	C51H66N10O12S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Valine, L-α-aspartyl-3-mercapto-L-valyl-L-phenylalanyl-D-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (2→7)-disulfide

参考文献

1. Patacchini R, et al. Br J Pharmacol. 2003 Dec;140(7):1155-8.

2. Camarda V, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):83-6.

Urantide

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Urantide

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