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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-UTE-156
UTE-156

Chemical Structure : UTE-156

CAS No.:

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UTE-156 (UTE156)

货号: PC-26295Not For Human Use, Lab Use Only.

UTE-156 is a potent, covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 10 nM, modifies Cys522 within the D2 ATPase domain of VCP.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UTE-156 is a potent, covalent small-molecule inhibitor of VCP/p97 AAA+ ATPase with IC50 of 10 nM, modifies Cys522 within the D2 ATPase domain of VCP.
The C522A mutant displayed markedly reduced sensitivity (IC50 >10 uM).
UTE-156 does not inhibit structurally related AAA+ ATPase Spastin, which does not contain cysteine in its Walker A motif.
UTE-156 reduced viability with an IC50 of 1.6 uM in A549 lung carcinoma cells, but not HCT116 colorectal carcinoma cells (IC50>100 uM).

物理化学性质&存储条件

分子量 396.43
分子式 C18H16N6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-((6-(1-methyl-1H-pyrazol-4-yl)-2-(methylsulfonyl)pyrimidin-4-yl)amino)phenyl)propiolamide

参考文献

1. amayo-Jaramillo D, et al. Adv Sci (Weinh). 2026 Mar 7:e20545.

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