UTBinh-14 (UT-B-IN-1)

Chemical Structure : UTBinh-14

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货号: PC-21373Not For Human Use, Lab Use Only.

UTBinh-14 (UT-B-IN-1) is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A.

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生物&药学活性

UTBinh-14 (UT-B-IN-1) is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A.
UTBinh-14 selectively and reversibly inhibited urea transport with IC50 of 25.1 nM and reduced urinary concentration in mice.

物理化学性质&存储条件

分子量	455.57
分子式	C20H17N5O2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-ethylphenyl)sulfonyl)-N-(thiophen-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

参考文献

1. M. O. Anderson, et al. J. Med. Chem. 55, 5942–5950 (2012).

2. Chi G, et al. Sci Adv. 2023 Sep 29;9(39):eadg8229.

UTBinh-14 (UT-B-IN-1)

生物&药学活性

物理化学性质&存储条件

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UTBinh-14 (UT-B-IN-1)

生物&药学活性

物理化学性质&存储条件

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