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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-USP inhibitor 1
USP inhibitor 1

Chemical Structure : USP inhibitor 1

CAS No.: 2064106-47-2

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USP inhibitor 1 (USP4 inhibitor)

货号: PC-73353Not For Human Use, Lab Use Only.

USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition.

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2 mg ￥2580 In stock
5 mg ￥3980 In stock
10 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition in U2OS cells.

物理化学性质&存储条件

分子量 290.747
分子式 C15H15ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-benzyl-4-(2-chloroacetyl)-1-methyl-1H-pyrrole-2-carboxamide

参考文献

1. Ward JA, et al. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272.

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