USP8 inhibitor W-17

Chemical Structure : USP8 inhibitor W-17

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货号: PC-27996Not For Human Use, Lab Use Only.

USP8 inhibitor W-17 is a potent, selective USP8 inhibitor with IC50 of 108 nM, exhibits no activity against USP7, USP10, and USP14 (IC50>10 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP8 inhibitor W-17 is a potent, selective USP8 inhibitor with IC50 of 108 nM, exhibits no activity against USP7, USP10, and USP14 (IC50>10 uM).
W-17 can stabilize USP8 in HCT116 and SW480 cells.
W-17 exhibits minimal inhibitory effects on USP family deubiquitinases, including USP7, USP10, and USP14.
W-17 directly engages USP8 in cells and accelerates PD-L1 proteasomal degradation via enhanced K48-linked polyubiquitination.
W-17 can promote the destabilization of PD-L1 and enhance T-cell mediated tumor cell killing activity.
W-17 (10-20 mg/kg/day) suppresses tumor growth and promotes immune activation in immunocompetent CT26 colorectal cancer model.

物理化学性质&存储条件

分子量	308.36
分子式	C13H16N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1,1-dioxidothiomorpholino)(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol-2-yl)methanone

参考文献

1. Zhiyu Song, et al. Transl Oncol. 2026 Aug 5:72:102956.