USP24-i-101 | USP24 inhibitor | Probechem Biochemicals

Chemical Structure : USP24-i-101

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USP24-i-101 (Compound 677-8)

货号: PC-24713Not For Human Use, Lab Use Only.

USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively.

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100 mg		Get quote

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生物&药学活性

USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively.
USP24-i-101 can dramatically induce autophagy through upregulation of ULK1, LC3 and ULK phosphorylation at Ser555 in lung cancer to negatively regulate drug resistance.
USP24-i-101 is better than USP24-i (NCI677397) in the inhibition of drug resistance in Taxol-induced drug resistant A549 cells (A549-T24).
USP24-i-101 inhibits drug resistance in EGFRL858R lung cancer drug resistant mice.
USP24-i-101 inhibits the expression of ABCG2 and PD-L1 and maintaining genomic integrity, resulting in the inhibition of drug resistance acquired by gefitinib- or Taxol-treatment of lung cancer.

物理化学性质&存储条件

分子量	429.58
分子式	C26H27N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(10-(2-(4-methylpiperazin-1-yl)ethyl)-10H-phenothiazin-2-yl)(phenyl)methanone

参考文献

1. Young MJ, et al. Cell Death Differ. 2024 May;31(5):574-591.

USP24-i-101 (Compound 677-8)

生物&药学活性

物理化学性质&存储条件

参考文献

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USP24-i-101 (Compound 677-8)

生物&药学活性

物理化学性质&存储条件

参考文献

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