USP1 inhibitor 38a

Chemical Structure : USP1 inhibitor 38a

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货号: PC-28121Not For Human Use, Lab Use Only.

USP1 inhibitor 38a is a potent, oral bioavailable deubiquitinating enzyme USP1 inhibitor, dose-dependently induces Ub-PCNA accumulation, triggers cell cycle arrest, and potently suppresses cell viability.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP1 inhibitor 38a is a potent, oral bioavailable deubiquitinating enzyme USP1 inhibitor, dose-dependently induces Ub-PCNA accumulation, triggers cell cycle arrest, and potently suppresses cell viability.
USP1 inhibitor 38a synergized with olaparib in MDA-MB-463 cells.
USP1 inhibitor 38a effectively induced c-MYC downregulation.
The combination of 38a with olaparib exerted potent antitumor efficacy in MDA-MB-436 xenograft model.

物理化学性质&存储条件

分子量	518.54
分子式	C28H25F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-4-methyl-1-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)benzyl)-1H-pyrrolo[3,2-c]pyridine

参考文献

1. Yang T, et al. J Med Chem. 2026 Sep 10;69(17):20403-20432.