USP14 inhibitor AKOS | USP14 inhibitor | Probechem Biochemicals

Chemical Structure : USP14 inhibitor AKOS

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USP14 inhibitor AKOS (AKOSB018304)

货号: PC-25113Not For Human Use, Lab Use Only.

USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor.

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生物&药学活性

USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor.
AKOS directly binds to USP14, covalently modifying the active-site cysteine residue (Cys114), thereby effectively inhibiting its deubiquitinase activity.
AKOS destabilizes its substrate MEF2D and inhibits the transcription of genes involved in the ECM-receptor interaction pathway in CRC.
AKOS significantly inhibited the proliferation and metastasis of CRC cells in vitro with IC50 values of 9.88 and 16.57 μM, respectively, in SW620 cells and HCT116 cells.
AKOS (15, 30 mg/kg, every 5 days) effectively suppressed the tumor growth in HCT116 xenograft mouse models in vivo.

物理化学性质&存储条件

分子量	266.29
分子式	C10H6N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(2-nitrobenzylidene)-2-thioxothiazolidin-4-one

参考文献

1. Lu B, et al. Acta Pharmacol Sin. 2025 Jul 17. doi: 10.1038/s41401-025-01616-5.

2. Jadav SS, et al. Eur J Med Chem. 2015 Jan 7;89:172-8.

USP14 inhibitor AKOS (AKOSB018304)

生物&药学活性

物理化学性质&存储条件

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USP14 inhibitor AKOS (AKOSB018304)

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物理化学性质&存储条件

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