USP10 inhibitor LY-2

Chemical Structure : USP10 inhibitor LY-2

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货号: PC-25142Not For Human Use, Lab Use Only.

USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM.
LY-2 (10 uM) induces the degradation of USP10 downstream protein YAP and p53 in Huh-7 cells.
LY-2 suppresses the growth of HCC cells by triggering apoptotic pathways, exhibits proliferation inhibition potency in Huh-7 with IC50 of 0.5 uM.
LY-2 inhibits USP10, thereby promoting YAP degradation, which affects the expression of CDK4 and CCNB2 within the p53 signaling pathway and ultimately leads to apoptosis in HCC cells.

物理化学性质&存储条件

分子量	487.98
分子式	C28H26ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((4-chlorophenethyl)amino)-2-oxoethyl)-7-methyl-4-oxo-N-(o-tolyl)-1,4-dihydroquinoline-2-carboxamide

参考文献

1. Lu Y, et al. Bioorg Chem. 2025 Jul 18;163:108775.