USP10 inhibitor D1

Chemical Structure : USP10 inhibitor D1

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货号: PC-22313Not For Human Use, Lab Use Only.

USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.
USP10 inhibitor D1 does not inhibit the deubiquitinase activity of USP7 at 10 uM.
USP10 inhibitor D1 inhibits the proliferation of hepatocellular carcinoma cell (Huh-7, IC50=2.3 uM) by inducing cell apoptosis and S-phase arrest.
USP10 inhibitor D1 inducing the degradation of USP10-related substrate protein by inhibiting USP10.

物理化学性质&存储条件

分子量	512.99
分子式	C29H25ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenethyl)-2-(7-methyl-4-oxo-3-(3-(o-tolyl)-1,2,4-oxadiazol-5-yl)quinolin-1(4H)-yl)acetamide

参考文献

1. Yang Lu, et al. Eur J Med Chem. 2024 May 5:272:116468.