URAT1 inhibitor TD-3

Chemical Structure : URAT1 inhibitor TD-3

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货号: PC-24745Not For Human Use, Lab Use Only.

URAT1 inhibitor TD-3 is a potent, selective inhibitor of urate transporter 1 (URAT1), inhibits URAT1-mediated 14C-UA uptake with IC50 of 1.36 uM.

规格	价格	库存	数量
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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

URAT1 inhibitor TD-3 is a potent, selective inhibitor of urate transporter 1 (URAT1), inhibits URAT1-mediated 14C-UA uptake with IC50 of 1.36 uM.
TD-3 shows favorable safety profiles, and no obvious acute toxicity was observed in Kunming mice under a single dose of 1000 mg/kg.
TD-3 has excellent ability to lower serum urate in vivo.
TD-3 has avorable safety and pharmacokinetic properties, oral bioavailability, and potent in vitro inhibition (IC50 1.36 µM), surpassing lesinurad in all aspects.

物理化学性质&存储条件

分子量	456.36
分子式	C21H18BrN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-((4-Bromonaphthalen-1-yl)methyl)-1H-imidazo[4,5-b]pyridin-2-yl)thio)-2-methylpropanoic Acid

参考文献

1. Suo Y, et al. Nat Commun. 2025 Jun 4;16(1):5178.

2. Tong Zhao, et al. J Med Chem. 2022 Mar 10;65(5):4218-4237.