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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-UP163
UP163

Chemical Structure : UP163

CAS No.: 591242-60-3

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UP163 (UP-163)

货号: PC-27882Not For Human Use, Lab Use Only.

UP163 is a small molecule allosteric activator of VCP ATPase activity with EC50 of 9.0 uM and Emax of 204%, exhibits ATPase domain–specific effects, enhances clearance of intranuclear TDP-4FL inclusions in cells expressing GFP-TDP-4FL.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UP163 is a small molecule allosteric activator of p97/VCP ATPase activity with EC50 of 9.0 uM and Emax of 204%, exhibits ATPase domain–specific effects, enhances clearance of intranuclear TDP-4FL inclusions in cells expressing GFP-TDP-4FL.

物理化学性质&存储条件

分子量 430.86
分子式 C20H15ClN2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-Chlorophenyl)(1,1-dioxidobenzo[d]isothiazol-3-yl)amino)ethyl furan-2-carboxylate

参考文献

1. Phan JM, et al. J Clin Invest. 2024 May 23:e169039.

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