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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-UOM-005636
UOM-005636

Chemical Structure : UOM-005636

CAS No.:

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UOM-005636 (UOM005636)

货号: PC-27703Not For Human Use, Lab Use Only.

UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex.

物理化学性质&存储条件

分子量 418.53
分子式 C22H18N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(pyridin-2-yl)phenyl)-N-(5-((pyridin-3-ylmethyl)thio)thiazol-2-yl)acetamide

参考文献

1. Moison C, et al. EMBO Rep. 2025 Jun;26(11):2836-2854.

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