UNC-2170 maleate | 53BP1 inhibitor | Probechem Biochemicals

Chemical Structure : UNC-2170 maleate

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UNC-2170 maleate (UNC2170 maleate)

货号: PC-62385Not For Human Use, Lab Use Only.

UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.

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生物&药学活性

UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
UNC-2170 maleate is highly cell permeant with no significant measureable cellular efflux.
UNC-2170 maleate shows modestly potent, demonstrates at least 17-fold selectivity for 53BP1 as compared to nine other Kme reader proteins.

物理化学性质&存储条件

分子量	429.3
分子式	C18H25BrN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-bromo-N-(3-(tert-butylamino)propyl)benzamide maleate

参考文献

1. Perfetti MT, et al. ACS Chem Biol. 2015 Apr 17;10(4):1072-81.

UNC-2170 maleate (UNC2170 maleate)

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UNC-2170 maleate (UNC2170 maleate)

生物&药学活性

物理化学性质&存储条件

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