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首页-小分子抑制剂&激动剂-Apoptosis-TNF Receptor-UMR2-705
UMR2-705

Chemical Structure : UMR2-705

CAS No.:

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UMR2-705 (Asp-Leu-Leu-Ile-Ser-Ile-Tyr)

货号: PC-26134Not For Human Use, Lab Use Only.

UMR2-705 is a novel Tumor Necrosis Factor Receptor 2 (TNFR2) agonist peptide, promotes Tregs expansion without affecting CD8+ T cells or conventional effector T cells (Teffs), acting through TNFR2 signaling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UMR2-705 is a novel Tumor Necrosis Factor Receptor 2 (TNFR2) agonist peptide, promotes Tregs expansion without affecting CD8+ T cells or conventional effector T cells (Teffs), acting through TNFR2 signaling.
UMR2-705 induces dose-dependent expansion of Tregs in murine CD4+ T cells and human PBMCs. selectively promotes Treg expansion through TNFR2 signaling.
UMR2-705 (25 mg/kg/day x 3 days) increases the proportion of Tregs in the spleen and lymph nodes in Balb/c mice.
UMR2-705 mitigates LPS-induced systemic inflammation and cytokine production, promotes dendritic cell accumulation in vivo and enhances their capacity to expand regulatory T cells in vitro.
UMR2-705 activates inflammation-associated signaling pathways, increases expression of multiple members of the TNF receptor superfamily, including Tnfrsf10b (TRAILR2), Tnfrsf9 (4-1BB), Tnfrsf18 (GITR), Tnfrsf1b (TNFR2), and Tnfrsf4 (OX40), on CD4+ T cells.

物理化学性质&存储条件

分子量 836.00
分子式 C40H65N7O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,5S,8S,11S,14S,17S,20S)-20-amino-5,11-di((S)-sec-butyl)-2-(4-hydroxybenzyl)-8-(hydroxymethyl)-14,17-diisobutyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid

参考文献

1. Ping Liao, et al. Front Immunol. 2025 Nov 26:16:1696587.

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