UMB298 | CBP/P300 inhibitor | Probechem Biochemicals

Chemical Structure : UMB298

CAS No.: 2266569-73-5

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UMB298 (UMB-298)

货号: PC-26728Not For Human Use, Lab Use Only.

UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
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生物&药学活性

UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4.
UMB298 inhibits MOLM13 cell growth with IC50 of 1.74 uM, reduces the H3K27ac level and causes MYC depletion.

物理化学性质&存储条件

分子量	479.02
分子式	C27H31ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine

参考文献

1. Alex Muthengi, et al. J Med Chem. 2021 May 13;64(9):5787-5801.

UMB298 (UMB-298)

生物&药学活性

物理化学性质&存储条件

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UMB298 (UMB-298)

生物&药学活性

物理化学性质&存储条件

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