UK5099 (PF-1005023) | MPC blocker | Probechem Biochemicals

Chemical Structure : UK5099

CAS No.: 56396-35-1

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UK5099 (PF-1005023, UK-5099)

货号: PC-38841Not For Human Use, Lab Use Only.

UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.
UK 5099 is a potent non-competitive inhibitor of pyruvate oxidation in castor-bean mitochondria.
UK 5099 impaired glucose tolerance in vivo.

物理化学性质&存储条件

分子量	288.3
分子式	C18H12N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

参考文献

1. Parvin R, et al. J Biol Chem. 1978 Mar 25;253(6):1944-6.

2. Brailsford MA, et al. Biochem J. 1986 Oct 15;239(2):355-61.

3. Patterson JN, et al. J Biol Chem. 2014 May 9;289(19):13335-46.

UK5099 (PF-1005023, UK-5099)

生物&药学活性

物理化学性质&存储条件

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UK5099 (PF-1005023, UK-5099)

生物&药学活性

物理化学性质&存储条件

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