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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-UCT594
UCT594

Chemical Structure : UCT594

CAS No.: 2044523-95-5

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UCT594 (UCT-594)

货号: PC-22969Not For Human Use, Lab Use Only.

UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.
    UCT594 inhibits P. falciparum asexual blood-stage activity.
    UCT594 is active against most stages of the parasite life cycle in vitro.
    UCT594 demonstrates concentration-dependent killing in the P. falciparum-infected NSG mouse model.

    物理化学性质&存储条件

    分子量 359.31
    分子式 C18H12F3N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)benzoic acid

    参考文献

    1. Gibhard L, et al. Antimicrob Agents Chemother. 2024 Aug 28:e0084224.

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